Dedicated Electrochemistry/UHPLC System

for EC/LC/MS

  • Fast metabolic screening of numerous samples
  • On-line EC/LC/MS of complex samples
  • Compatibility with any MS via contact closure
  • Mimicking oxidative stress/damage of proteins, DNA, lipids, etc.
  • Simulating nature’s Redox reaction

With the introduction of the ROXY™ EC/LC System, Antec brings Electrochemistry (EC) to the fingertips of every mass spectrometrist. It makes on-line EC/LC/MS for automated screening of numerous samples available for the first time. The system is based on state-of-the-art fluidics, implementing the ReactorCell™ as part of the autosampler. Furthermore specifically designed liquid handling programs allow for the addition of reagents, making Phase II reactions, i.e., adduct formation, in drug/xenobiotic metabolism easily accessible. Other applications include the studies of covalent drug-protein binding or the studies of reagents, e.g., antioxidants on biopolymers and their biotransformation (patent pending).
The system further comprises a binary high pressure gradient system to assure minimal dwell volume and access to a wide flow rate range, covering conventional HPLC (4.6 mm i.d. columns) down to microbore HPLC (1 mm i.d. columns).



  • 2014 – Productflyer ROXY




  • 221_070_01 – Online EC MS A Powerful Tool for Fast Prediction of Phase I and II Drug Metabolism
  • 221_076_01 – Expanding Role of Electrochemistry Mass Spectrometry in Life Sciences
  • 221_077_01 – Novel method for efficient reduction of disulfide bonds in peptides and proteins prior MS detection
  • 221_078_01 – Identification of electrochemically synthesized metabolites
  • 221_079_01 – Insights into Nucleic Acids Oxidation by ElectrochemistryLiquid ChromatographyMass Spectrometry
  • 221_090_01 – Degradation of Xenobiotics and Binding to Organic Matter by OnLine EC MS
  • 221_105_01 – Controlled Reduction of Disulfide Bonds in Biopharmaceuticals Using an Electrochemical Reactor Cell online with LCMS Rolduc 2014
  • 221_106_01 – ElectrochemistryMS a Powerful Tool in Drug Metabolism Rolduc 2014
  • 221_107_01 – ElectrochemistryMS a Powerful Tool in Drug Metabolism ASMS 2014
  • 221_108_01 – Controlled Reduction of Disulfide Bonds in Proteins and Peptides Using an Electrochemical Reactor Cell in online LCECMS ASMS 2014
  • 221_115_01 – Controlled Reduction of Disulfide Bonds in Biopharmaceuticals ElCheMS2015
  • 221_116_01 – Enhanced Pharmaceutical Stability ElCheMS2015
  • 221_117_01 – Mimicking Drug Metabolism ElCheMS2015
  • 221_118_01 – Electrochem Reduction of Disulfide Bonds ASMS2015
  • 221_120_01 – ECHDX for the Analysis of Protein Therapeutics HOS2015