CTS
Assay and content/blend uniformity for up to 240 samples High-throughput, multi-sample process
ing 25 – 1000 mL initial extraction volume Extraction from large dosage forms (up to 30 mm)
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Extraction |
After we ighing the sample, the CTS uses a hig shear homogenizer probe to quickly extract samples. With this tool, the CTS can achieve efficient and reproducible extraction for even the most challenging dosage forms. Efficient cleaning of the extraction tool using a wash station between samples is easily programmed into the method to eliminate sample carry-over. The CTS actively uses three extraction vessels to allow for increased sample throughput. |
Filtration & Dilution |
The CTS filters extracted samples as they are transferred from the extraction vessel to processing tubes. Post filtration, the system can perform up to 1:20,000 dilutions within a single method. The volumes for all liquid handling operations are confirmed gravimetrically for added accuracy and precision. For every sample, the system audit trail combined with the advanced error handling capabilities provides a detailed and comprehensive record of the entire preparation process. |
Analysis & Storage |
CTS can use up to 2 HPLC injectors to support on-line HPLC analysis. Samples can also be collected in sealed HPLC vials. Optionally, the samples can be stored in a chilled environment. For samples requiring UV analysis, CTS can act as an on-line autosampler. This can be done using the CTC sample handler after dilution or the UV in-line function using optical dilutions. The CTS will then use an analog connection to trigger the UV to read the sample in accordance with the external UV instrument control program. |