Sample Preparation Workstation.

טוטAssay and content/blend uniformity for up to 100 samples 20 – 520 mL initial extraction volume Waters Empower™ Interface Powerful dEsign™ variables for streamlined DoE studies


After weighing the sample, the TPW uses a high-shear homogenizer to provide a consistent wet grinding process to quickly extract samples. With this tool, the TPW can achieve efficient and reproducible extraction for even the most challenging dosage forms. Common sample types include traditional solid oral dosage forms including tamper-resistant products, osmotic pump, modified/extended and delayed release formulations. Cleaning between samples is easily programmed into the method to eliminate sample carry-over. The updated TPW is enhanced to reduce cycle times by adding efficiency to the clean-up and dilution processes.

Filtration & Dilutioncsm_sotax_asp_filtration_dilution_24fe4509b1

 Consistent volumetric preparations are confirmed gravimetrically at every step throughout the  process. The TPW uses a fluid metering pump to filter extracted samples as they are  transferred from the extraction vessel to processing tubes. Post filtration, the system can  perform up to 1:100,000 dilutions within a single method. For every sample, the system audit  trail combined with the advanced error handling capabilities provides a detailed and  comprehensive record of the entire preparation process.

Analysis & Storagecsm_sotax_asp_analys_storage_e239596595

 The built-in HPLC injector supports on-line analysis. Optionally, all pertinent sample    information is transferred to Empower ™ as the sample sequence is built by the interface as  the  TPW run list progresses. In addition  to on-line HPLC analysis, samples can also be  collected in  sealed HPLC vials on the  autosampler. Finally, the TPW has the capability to  transfer samples  to a UV  spectrophotometer to act as an autosampler for on-line UV analysis.