High efficiency separations at any pH

The Hamilton PRP-C18 is a new HPLC column designed to provide high-efficiency, reversed-phase separations over an extended column life in nearly any mobile phase or pH. The rigid stationary phase has excellent mechanical and thermal stability (> 100°C), does not shrink or swell, and is completely inert to most conditions commonly encountered in reversed-phase chromatography.
The PRP-C18 is a durable and effective column for general purpose HPLC and especially well-suited for specialized applications in the clinical, pharmaceutical, environmental, food, forensics, and life sciences industries.

Oligonucleotide Purification

The properties of the PRP-C18 make it a superior column in the field of oligonucleotide purifications, providing:

  • Superior resolution for purer oligos
  • Extended column lifetime for increased productivity
  • High loading capacity for time and cost savings


Organic compounds: small molecules (< 2,000 mw), pharmaceuticals, steroids, halides, vitamins, amino acid analysis, herbicides

Examples of analytes that can be separated on PRP-C18 columns:

  • PeptidesDNA
  • RNA oligonucleotides
  • Vitamins
  • Steroids
  • Herbicides
  • Pharmaceutical compounds

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